Have you been feeling unusually sleepy or excessively hungry of late? If you have, it may be the fault of a neuropeptide called Orexin. Your brain has approximately 70,000 neurons that produce Orexin. The neurons originate in your hypothalamus and extend all the way through your brain and spine. Discovered in 1998 it is now known to be responsible for your feeling of hunger, feeling of wakefulness and even in the digestion of lipids. There are two classes Orexin A and Orexin B.

If your Orexin generation is amiss, you might feel excessively sleepy during the day and find yourself unable to sleep during the night. An excess production of Orexin will result in a hyperactive state, an increase in body temperature and excessive burning of calories. All of this will result in a significant increase in the craving of food and meal size. As a result, your bodies regulatory mechanism that tells you when to stop eating will be thrown out of gear. Orexin is also responsible for energy balance in your body – the manner in which your body regulate your body weight.

The secretion of Orexin can be triggered by a wide variety of reason. Some of these triggers include a change in environment, lifestyle changes, metabolic signals including being unwell or feeling fatigue.

There are several supplements and medication available that help you regulate the production of Orexin. The best natural ways to achieve similar results include the consumption of Omega 3 Fatty Acids, found in walnuts, flax seeds, etc., drinking caffeine, spending time in natural sunlight or bright lights, exercise, consumption of lactobacillus found in yogurt and a diet low in carbohydrate and high in protein. In short, living a good healthy lifestyle and eating quality food. Arent you, my reader, doing that already?


Ritesh is a born again health enthusiast and holds a Certificate in Physiology from Harvard Medical School and a Certificate in Nutrition from Tufts University.