Krebs cycle and a Broken Metabolism

The manner in which the food that you consume is broken down into its end product is known as the Krebs or Citric Acid Cycle. The Krebs Cycle is a series of chemical reactions used by all aerobic organisms to release stored energy. In plain language, this means to break down the nutrition in your food – carbohydrates, proteins and fats et al. into for example muscle. Scientists theorise that this may have been one of the earliest processes in living organisms. It is also known as the Citric Acid Cycle as citric acid dominates this process. The Krebs Cycle is the energy pathway you are using for long duration endurance, for example, running a marathon, as it is the slowest acting energy pathway. Also, it is the only path that uses fat in addition to carbs and protein for energy production.

Sometimes this process breaks down. The usual process by which nutrition is converted into energy is interrupted. This interruption occurs in your immune cells such as macrophages and leads to a broken cycle. A breakdown can affect your metabolism and therefore your body to convert food into energy. A research team at the Imperial College, London, conducted a research study to attempt to heal this energy pathway. They found that during the breakdown, an enzyme called BCAT1 was involved in creating the diversion. If you could block the enzyme by flooding it with a compound, you could block the specific branching or their activity reducing the damage caused by inflammation. The researchers found that for example, the effects of rheumatoid arthritis was significantly reduced in mice by injection them with this compound.

Inflammation of your body is perhaps cumulatively one of the worst causes of disease and death in modern society. I had no idea what it even meant a few years ago.


Ritesh is a born again health enthusiast and holds a Certificate in Physiology from Harvard Medical School and a Certificate in Nutrition from Tufts University.